Effectiveness and tolerability of eight-week treatment with dosulepin hydrochloride in patients with major depressive disorder not responding to four consecutive weeks of treatment with single selective serotonin reuptake inhibitor

Background: Though manageable, major depressive disorder remains an underdiagnosed and undertreated condition. The objective of this study was to assess the effectiveness safety 8 weeks treatment with tricyclic antidepressant dosulepin hydrochloride in patients episodes not responsive 4 consecutive a single selective serotonin reuptake inhibitor (SSRI).Methods: Patients diagnosed episode without psychotic symptoms (by ICD-10 diagnostic criteria for research), mini-mental state examination score ≥24, four SSRIs (<50% reduction symptoms) were enrolled. main outcome measures mean change Hamilton depression, anxiety, insomnia severity index scores at Week compared baseline. Adverse events recorded assessment.Results: A total 94 enrolled, which, 90 (95.7%) completed study. Compared baseline, significantly changed HAM-D by -12.7 (p<0.0001), HAM-A -8.3 ISI -10.5 (p<0.0001). One patient reported anemia withdrawn from Dry mouth followed headache, blurred vision, drowsiness most commonly side effects as measured side-effects checklist. Most mild intensity related medication.Conclusions: Eight resulted significant clinically relevant improvements Indian MDD.